THE Fiona Elsey Cancer Research Institute is the recipient of a Perpetual 2021 IMPACT Philanthropy program grant with the money going towards boosting the facility\u2019s triple negative breast cancer research.<\/p>\n
The Harry Secomb Foundation and William G. Maxwell Trust have awarded the funding to head of breast cancer research Dr Aparna Jayachandran and her team including co-investigators Professor George Kannourakis, Dr Prashanth Prithviraj, and South Australia Health and Medical Research Institute\u2019s Dr Sushma Rao.<\/p>\n
\u201cTriple negative breast cancers affect more than 300,000 women worldwide annually, and causes about 25 per cent of all breast cancer-related deaths,\u201d Dr Jayachandran said.<\/p>\n
\u201cIt\u2019s the deadliest form of breast cancer because currently there is no targeted drug therapy available and no biomarker or indicator that allows us to monitor the aggressiveness of this disease.<\/p>\n
\u201cThis grant will allow us to address these two very crucial clinical problems in triple negative breast cancer.\u201d<\/p>\n
In 2020, the FECRI team identified a link between high levels of the PAPP-A protein – pregnancy associated plasma protein – with poor survival in triple negative breast cancer patients.<\/p>\n
For this reason, the PAPP-A protein is at the centre of further investigation.<\/p>\n
\u201cThe goal for this project now is to establish whether PAPP-A can be a potential biomarker that can help us reliably monitor the aggressiveness of triple negative breast cancers, and secondly, we are studying the protein network of PAPP-A to identify potential and robust drug targets,\u201d Dr Jayachandran said.<\/p>\n
\u201cIf successful, this project can lead to potential breakthroughs in the areas of biomarker, drugs or therapy, and improve the outlook of all individuals who are affected by triple negative breast cancer, so we\u2019re very grateful for this boost the grant is providing us for the next 12 months.<\/p>\n
\u201cIf we didn\u2019t get the funding from our Ballarat community as well, our research would not be possible. It\u2019s helped us identify a very important protein.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"
THE Fiona Elsey Cancer Research Institute is the recipient of a Perpetual 2021 IMPACT Philanthropy program grant with the money going towards boosting the facility\u2019s triple negative breast cancer research. The Harry Secomb Foundation and William G. Maxwell Trust have awarded the funding to head of breast cancer research Dr Aparna Jayachandran and her team […]<\/p>\n