{"id":184569,"date":"2026-04-13T04:00:00","date_gmt":"2026-04-12T18:00:00","guid":{"rendered":"https:\/\/timesnewsgroup.com.au\/surfcoasttimes\/?p=184569"},"modified":"2026-04-14T09:30:44","modified_gmt":"2026-04-13T23:30:44","slug":"trial-to-reduce-preschool-wheezing-episodes","status":"publish","type":"post","link":"https:\/\/timesnewsgroup.com.au\/surfcoasttimes\/living\/trial-to-reduce-preschool-wheezing-episodes\/","title":{"rendered":"Trial to reduce preschool wheezing episodes"},"content":{"rendered":"

A MAJOR clinical trial aiming to reduce hospital admissions for wheezing preschoolers has reached a significant milestone.<\/p>\n

The ARROW (Assessing the Reduction of Recurrent admissions using OM-85 for the treatment of preschool Wheeze) trial is testing a new treatment for childhood wheeze.<\/p>\n

It involves 46 hospitals participating in the Children’s Inpatient Research Collaboration of Australia and New Zealand (CIRCAN) and recently recruited its 1,000th child.<\/p>\n

Study lead Professor Peter Vuillermin, a paediatrician from the Barwon Health and Deakin University Clinical Trials Alliance, said wheezing illnesses were the leading global cause of hospital admissions among preschool-aged children.<\/p>\n

“Wheeze episodes are distressing for children and their families and are a strong predictor of asthma in later life,” he said.<\/p>\n

“Over a third of young children admitted to hospital with a wheeze episode will be readmitted within a year with another episode. Unfortunately, we still don’t have a treatment that we know substantially reduces this risk.<\/p>\n

“There is strong evidence that children who are exposed to a wider range of environmental bacteria in early life, such as those who grow up on farms with livestock, have lower rates of wheezing illnesses and asthma.”<\/p>\n

Part of the trial involves the testing of OM-85. an oral medication that boosts immunity by delivering a dose of inactive (broken-down) bacteria, which is effective in preventing hospital admissions among young children with recurrent, severe wheezing illnesses.<\/p>\n

Dr Jessica Costa-Pinto, a paediatrician and PhD scholar, said previous studies had shown OM-85 could reduce respiratory tract infections and may reduce wheeze episodes in children.<\/p>\n

“This large clinical trial will tell us if it can also prevent hospital admissions from wheeze,” she said.<\/p>\n

Xander Gillin, three, is one of the 1,000 participants who have signed up for far in the ARROW Trial.<\/p>\n

Xander has been in hospital with wheeze episodes eight times in the space of 18 months.His mum, Amanda, is hopeful the trial will identify effective treatment to reduce these episodes.<\/p>\n

The trial is a randomised, double-blind, placebo-controlled trial that aims to eventually recruit 1,088 children aged between one and six with a history of recurrent wheeze requiring hospital admission.<\/p>\n

Participants receive either OM-85 or a placebo for the first 10 days of each month over 12 months.<\/p>\n

Families complete weekly electronic diaries to track respiratory symptoms and healthcare presentations, and information about hospital presentations is collected using medical records.<\/p>\n

A specially developed web application allows clinicians from participating CIRCAN hospitals to refer patients to the trial.<\/p>\n

Families of children aged between one and six who have a wheeze-related hospital admission in the past 12 months can also self-refer.<\/p>\n

Professor Vuillermin said reaching the milestone of 1,000 children reflected the extraordinary commitment of paediatric doctors and nurses, researchers, and the participating families.<\/p>\n

“The ARROW Trial has the potential to improve the health of kids with recurrent wheezing illnesses in Australia, New Zealand and around the world. It has been a huge collective effort, and we are very proud of our team and grateful to all who have contributed,” Dr Costa-Pinto said.<\/p>\n

Funding for the ARROW Trial has been provided by the National Health and Medical Research Council (NHMRC), Cure Kids, the Starship Foundation, and OM-Pharma.<\/p>\n

Clinicians or families interested in becoming involved can email the team at arrowtrial@deakin.edu.au<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A MAJOR clinical trial aiming to reduce hospital admissions for wheezing preschoolers has reached a significant milestone. The ARROW (Assessing the Reduction of Recurrent admissions using OM-85 for the treatment of preschool Wheeze) trial is testing a new treatment for childhood wheeze. It involves 46 hospitals participating in the Children’s Inpatient Research Collaboration of Australia […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":26,"featured_media":184754,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[26],"tags":[],"post_folder":[],"class_list":["post-184569","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-living"],"acf":[],"yoast_head":"\nTrial to reduce preschool wheezing episodes - Surf Coast Times<\/title>\n<meta name=\"description\" content=\"The ARROW Trial reaches 1,000 participants testing OM-85 to reduce hospital admissions for preschool children with recurrent wheezing episodes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/timesnewsgroup.com.au\/surfcoasttimes\/living\/trial-to-reduce-preschool-wheezing-episodes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trial to reduce preschool wheezing episodes - 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